Dr. Victor Biton is the owner and director of Arkansas Epilepsy Program. In 1990, Dr. Biton completed his specialty training in epilepsy in Minneapolis, Minnesota. Shortly therafter, Dr. Biton and his family decided to relocate to Little Rock, Arkansas where Dr. Biton served as the Director of the Epilepsy Program at UAMS and the VA hospital. In 1994 Dr. Biton started his own private practice, Arkansas Epilepsy Program, to serve as a comprehensive epilepsy program serving Arkansas and the surrounding areas.
AEP strives to hire and retain the most experienced and specialized staff in the area. Our staff includes EEG technicians with many years of experience, trained lab technicians, an experienced specialty nurse, and support operations contracted through a major hospital system in the area (www.practice-plus.com).
Dr. Biton is considered one of the foremost experts in his field; below are some of his many publications from recent years.
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| The Staff of Arkansas Epilepsy and Clinical Trials Incorporated |
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| Dr. Victor Biton |
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Articles
Biton V. The Treatment of Epilepsy (Shorvon S, Perucca E, Engel J, eds.). 3rd ed., Blackwell Publishing, 2009 (chapter 51:Rufinamide; 647-657).
Sadercock D, Cramer M, Wu J, Chiang Y, Biton V, Heritier M. Gabapentin Extended Release for the Treatment of Painful Diabetic Neuropathy: Efficacy and Tolerability in a Double-blind, Randomized, Controlled Clinical Trial. Diabetes Care (online) Feb 2009; 32(2).
Biton V. Lamotrigine for Pediatric Patients with Epilepsy. Pediatric Health 2008; 2 (2); 125-134.
Biton V, Rosenfeld WE, Whitesides J, Fountain NB, Vaiciene N, Rudd GD. Intravenous Lacosamid as Replacement for Oral Lacosamide in Patients with Partial-Onset Seizures. Epilepsia 2008; 49(3); 418-424.
Biton V. Lacosamide for the Treatment of Diabetic Neuropathic Pain. Expert Review of Neurotherapeutics 2008; 8(11); 1649-1660.
Rauck RL, Shaibani A, Biton V, Simpson J, Koch B. Lacosamide in Painful Diabetic Neuropathy: A Phase 2 Double-Blind Placebo-Controlled Study. Clinical Journal of Pain 2007; 23(2): 150-158.
Biton V. Pharmacokinetics, Toxicology, and Safety of Lamotrigine in Epilepsy. Expert Opin Drug Metab Toxicol 2006; 2(6): 1009-1018.
Blum D, Meador K, Biton V, Fakhoury T, Shneker B, Chung S, Mills K, Hammer A, Isojärvi J. Cognitive Effects of Lamotrigine Compared with Topiramate in Patients with Epilepsy. Neurology 2006; 67(3): 400-406.
Biton V. Weight Change and Antiepileptic Drugs: Health Issues and Criteria for Appropriate Selection of an Antiepileptic Agent. Neurologist 2006; 12(3): 163-167.
Biton V, Sackellares JC, Vuong A, Hammer AE, Barrett PS, Messenheimer, JA. Double-Blind, Placebo-Controlled Study of Lamotrigine in Primary Generalized Tonic-Clonic Seizures. Neurology 2005; 65: 1737-1743.
Biton V, Bourgeois BFD. Topiramate in Patients with Juvenile Myoclonic Epilepsy. Archives of Neurology 2005; 62(11): 1705-1708.
Sale ME, Natarajan S, Biton V, Vuong A, Hammer AE, Messenheimer JA, Blum D. A Dosing Algorithm for Converting from Valproate Monotherapy to Lamotrigine Monotherapy in Patients with Epilepsy. Epilepsy and Behavior 2005; 6: 63-70.
Biton V. Zonisamide: New Antiepileptic Agent with Multiple Mechanisms of Action. Expert Rev Neurotherapeutics 2004; 4(6): 935-943.
Biton V. Rufinamide. In: Shorvon S, Perucca E, Fish D, Dodson E, eds. The Treatment of Epilepsy, 4th ed. Oxford: Blackwell Publishing, 2004; 43: 500-506.
Biton V. Antiepileptic Drugs and Weight Gain. SYCP Epilepsy 2003; 10(2): 3-6.
Abstracts
Krauss G, Yang J, Biton V, Klapper J, Bar M, Rektor I. Determination of Maximum Tolerated Dose (MTD), Safety, Efficacy, and Pharmocokinetics (PK) of Perampanel, a Selective AMPA receptor antagonist, as Adjunctive Therapy in Subjects with Refractory Partial Seizures. (Abstract presented at the 62nd Annual Meeting of the American Epilepsy Society 2008). Jatuzis D, Biton V, Ben-Menachem E, Abou-Khalil B, Doty P, Rudd GD. Evaluation of the Effect of Oral Lacosamide on Concomitant AED Plasma Concentrations in Patients with Partial Seizures. Epilepsia 2005; 46 Suppl.8: 170.
Lesser RP, Biton V, Sackellares JC, Van Ness PC, Perdomo C, Arroyo S. Efficacy and Safety of Rufinamide Monotherapy for the Treatment of Patients with Refractory Partial Seizures. Epilepsia 2005; 46 Suppl.8: 177-178.
Rosenfeld W, Biton V, Mameniskiene R, Vaiciene N, Whitesides J, Schiltmeyer B, Sommerville K. Pharmacokinetics and Safety of Intravenous Lacosamide Administered as Replacement for Adjunctive Oral Lacosamide in Patients with Partial-Onset Seizures. Epilepsia 2005; 46 Suppl.8: 184.
Sachdeo R, Porter R, Biton V, Rosenfeld W, Alves W, Nohria V. Dose Finding Study of Retigabine (A Novel AED) in Patients with Epilepsy. Epilepsia 2005; 46 Suppl.8: 185.
Biton V, Sachdeo R, Rosenfeld W, Schachter S, Perdomo C, Arroyo S. Efficacy and Safety of Adjunctive Rufinamide in Patients with Inadequately Controlled Primary Generalized Tonic-Clonic Seizures. Epilepsia 2005; 46 Suppl.8: 206.
Biton V, Vuong A, Kerls S, Hammer A, Messenheimer J. Onset of Efficacy with Lamotrigine in Primary Generalized Tonic-Clonic Seizures (PGTCS): A Randomized, Placebo-Controlled Study. Epilepsia 2005; 46 Suppl.8: 206.
Todorov A, Biton V, Krauss GL, Perdomo C, Arroyo S. Efficacy and Safety of High- Versus Low-Dose Rufinamide Monotherapy in Patients with Inadequately Controlled Partial Seizures. Epilepsia 2005; 46 Suppl.8: 218-219.
Biton V, Rosenfeld W, Mameniskiene R, Vaiciene N, Whitesides J, Sommerville K. Safety and Tolerability of Intravenous Lacosamide as Replacement for Oral Lacosamide in Subjects with Partial-Onset Seizures. Epilepsia 2005; 46 Suppl.6: 121.
Ben-Menachem E, Biton V, Jatuzis D, Abou-Khalil B, Doty P, Rudd D, S.P. 667 Study Group. Efficacy and Safety of Adjunctive Oral Lacosamide for the Treatment of Partial Onset Seizures in Patients with Epilepsy. Epilepsia 2005; 46 Suppl.6: 57.
Biton V, Groenke DA, Hammer AE, Kustra RP, Messenheimer JA, Winter P. Evaluation and Comparison of Seizure Control During Escalation of Lamotrigine, Valproic Acid, Carbamazepine and Phenytoin as Initial Monotherapy in Patients with Epilepsy. Eur J Neurol 2003; 10(1): 141.
Biton V, Whitesides J, Doty P, Sommerville K. Safety and Efficacy of SPM 927 during the Initial Phase of an Extension Trial in Subjects with Partial Seizures. Epilepsia 2003; 44 Suppl.9: 259.
Biton V, Bebin ME. Multicenter, Open-Label Assessment of the Efficacy and Safety of Zonisamide as Adjunctive Therapy for Primary Generalized Epilepsy. Epilepsia 2002; 43 Suppl.7: 2.180.
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OUR STAFF:
Barbara Schwerman, Senior Patient Accounts Representative - Barbara has worked with us for 11 years and has experience in a variety of medical insurance billing settings.
Betty Ussery, Research Coordinator - Betty has been with us about 9 years, and in her current position for about 3 years. Betty was recently certified as a Clinical Research Coordinator and is an active member of the Association of Clinical Research Professionals.
Brenda Harder, EEG Technician - Brenda has been with us for 7 years and is very experienced in performing Electroencephalography procedures.
Brenda Spann, Director of Neurophysiology - Brenda has more than 20 years of experience in her field, and has been with us for 11 years. She is very experienced in routine and ambulatory Electroencephalography procedures.
Cindy Burkhart, Labratory Technician - Cindy has 28 years of experience in her field and has been with us for about 4 years. She is an accomplished Phlebotomist and Medical Assistant.
Denise Davis, Research Coordinator - Denise has over 10 years experience in her field and has been with us for 5 years. She is a certified member of the Association of Clinical Research Professionals and has coordinated over 150 studies of multiple indications.
Donna Hemphill, Research Coordinator - Donna has been with us for 11 years and is a Registered Nurse as well as a tenured Research Coordinator and a member of the Association of Clinical Research Professionals.
Dusty Holderfield, Research Coordinator - Dusty has 10 years of experience in her field, and has spent all 10 years with us. She is a Registered Nurse, BSN, CCRC and a member of the Association of Clinical Research Professionals.
Jonathan Rushing, Clinic Manager - Jonathan has 10 years of experience as a healthcare manager. He has been with us for 4 years after serving as Executive Director of a Texas Easter Seals facility.
Judy Summers, Specialty Nurse - Judy is a Registered Nurse with over 20 years experience in her field. She has been with us for 17 years and is the founder and leader of the E.E.G.S. support group.
Kelly Threlkeld, Administrative Assistant - Kelly has more than 20 years experience in her field and has been with us for 15 years.
Kimberly Hagar, Contracts & Clincal Accounts Coordinator - Kimberly has 11 years of experience, which she obtained with us. She is a certified Neuropsychological Psychometrician, Certified Clinical Research Coordinator, and is a member of the Association of Clinical Research Professionals.
Kristin Miller, Research Coordinator - Kristin has been an LPN for 13 years and is working towards becoming an RN and Certified Clinical Research Coordinator. She began research duties in 2008 and joined our staff about 2 years ago.
Lauren Landers, Marketing Coordinator - Lauren has 8 years experience in her field and has been with us for 4 years. Lauren has extensive training in advertising, communications, and public relations.
Mark Franks, Regulatory Documents Coordinator - Mark has many years of experience in a variety of fields, and has been with us for about 4 years. Mark is currently pursuing a Master's Degree in his free time.
Mary Davis, Transcriptionist - Mary has been with us for about 2 years. Mary has 35 years of extensive medical transcription experience!
Ruth Mattingly, Front Office Representative - Ruth joined us in early 2008. She has many years experience in all aspects of front office operations. Ruth came to us after spending 18 years in a hospital setting.
Suzanne Steele, Senior Front Office Representative - Suzanne has 14 years of experience in her field and has been with us for over 4 years. Suzanne comes to us from the Seizure Investigation Unit at Baptist Hospital.
Teri Walters, Research Coordinator - Teri has been in her current position for about 4 years and has been with us for about 6 years. She is a certified Medical Technologist, Lab Technician, X-Ray Technician, and a Phlebotomist.
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